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1. What is toxicology’s main concern?
- Effects of toxins on the body
- Effects of drugs on the body
- Effects of drugs that induce disease
- Both (1) and (3)
Answer and Explanation
Answer: (1) Effects of toxins on the body
Explanation: Toxicology studies the impact of toxins on the body, including their actions, detection, and treatment and and autopsy findings (in case of death).
2. The origin of the word ‘Toxic’ is from:
- Latin ‘tox’, meaning poison
- Greek ‘tox’, meaning poison
- Latin ‘tox’, meaning bow
- Greek ‘tox’, meaning bow
Answer and Explanation
Answer: (4) Greek ‘tox’, meaning bow
Explanation:
-> The term “Toxic” originates from the Greek word ‘tox’, which means bow.
-> This is historically linked to the use of poisoned arrows in warfare.
3. Who is considered the ‘Father of Toxicology’?
- Mathieu Orfila, a Swiss-born Spanish toxicologist
- Mathieu Orfila, a Swiss-born French toxicologist
- Mathieu Orfila, a Swiss-born Scottish toxicologist
- Mathieu Orfila, a Spanish-born French toxicologist
Answer and Explanation
Answer: (4) Mathieu Orfila, a Spanish-born French toxicologist
Explanation:
-> Orfila, Mathieu (1787–1853), Spanish, French Forensic Toxicologist and chemist.
-> He was born in Spain but moved to France where he worked and became professor of forensic chemistry.
-> He also become the dean of the medical faculty at the University of Paris.
4. In which year was the ‘Treatise of General Toxicology’ published?
- 1814
- 1900
- 1850
- 1845
Answer and Explanation
Answer: (1) 1814
Explanation:
-> The ‘Treatise of General Toxicology’ or ‘Traité des poisons’ was published in 1814 by Mathieu Orfila.
-> It marks as a foundational moment in the development of modern toxicology.
5. Assertion (A): Anything can be considered a poison depending on its application and dosage.
Reason (R): A poison is defined not by the substance itself but by its effect on the body, whether through constitutional or local effects, leading to ill health or death.
Choose the correct option from the list:
- Both (A) and (R) are correct
- (A) is correct, but (R) is wrong
- (A) is wrong, but (R) is correct
- Both (A) and (R) are wrong
Answer and Explanation
Answer: (1) Both (A) and (R) are correct
Explanation: For example, water is essential for life but it can lead to water intoxication if consumed excessively.
6. How is a substance characterized as a poison in toxicology?
(a) Based on its physical state (solid, liquid, or gaseous)
(b) Through its ability to cause ill health or death
(c) By its use in medical treatment
(d) Depending on its availability in nature
(e) By its constitutional and local effects on the body
Choose the correct option from the list:
- (a) and (d)
- (b) and (e)
- (c) and (d)
- (b) and (c)
Answer and Explanation
Answer: (2) (b) and (e)
Explanation: A poison is characterized by its capacity to induce ill health or death, determined by its constitutional (systemic) or local effects on the body, rather than its physical state, natural occurrence, or medical applications.
7. Define clinical toxicology.
- The chemical exposure that cause diseases
- The cultivation of plants for toxin production.
- The historical use of poisons in warfare
- The study of poison resistance in wildlife.
Answer and Explanation
Answer: (1) Chemical exposure diseases
Explanation: Clinical toxicology deals with diseases caused by abnormal chemical exposure.
8. What distinguishes forensic toxicology from clinical toxicology?
(a) Forensic toxicology focuses on substances in the environment.
(b) Clinical toxicology is concerned with diseases caused by chemicals.
(c) Forensic toxicology involves legal aspects of chemical effects on humans.
(d) Clinical toxicology deals with the treatment of substance exposure.
(e) Forensic toxicology is limited to autopsy findings.
Choose the correct option from the list:
- (b) and (d)
- (c) and (e)
- (b), (c), and (d)
- (c) and (d)
Answer and Explanation
Answer: (4) (c) and (d)
Explanation:
-> Forensic toxicology deals with the medical and legal aspects of chemical substances’ effects on humans.
-> It focuses on identification, quantification, and interpretation of toxic substances in human tissues as well as the ability to interpret the results of one’s findings.
-> While clinical toxicology addresses the health impact and treatment of diseases caused by chemical exposures.
9. What is chronic poisoning?
- Rapid deterioration after a single exposure to a toxin
- Immediate death following toxin exposure without symptoms
- Gradual worsening caused by smaller doses over time
- A combination of acute and chronic symptoms after toxin exposure
Answer and Explanation
Answer: (3) Gradual worsening caused by smaller doses over time
Explanation:
-> Chronic poisoning is caused by repeated exposure to smaller doses of a toxin over an extended period, resulting in a gradual worsening of health rather than immediate severe symptoms.
-> Example: Continuous exposure to mercury can cause hatter’s shake.
10. What characterizes acute poisoning?
- A long-term exposure to a toxin
- A massive dose of poison leads to rapid death
- An excessive dose taken over a short interval of time
- Gradual worsening from smaller doses over time
Answer and Explanation
Answer: (3) An excessive dose taken over a short interval of time
Explanation:
-> Acute poisoning is characterized by the effects of an excessive single dose or several doses of a poison taken over a short interval of time, leading to immediate health impacts.
-> Example (Acute vs Chronic):
- Acute: Ingesting a large quantity of a toxic substance like arsenic in a single instance can cause acute poisoning with rapid onset of symptoms.
- Chronic: While long-term exposure to low levels of arsenic in drinking water may lead to chronic poisoning.
11. What characterizes subacute poisoning?
- It features only the symptoms of chronic poisoning
- It is another term for fulminant poisoning
- It occurs without any visible symptoms
- It shows features of both acute and chronic poisoning
Answer and Explanation
Answer: (4) It shows features of both acute and chronic poisoning
Explanation:
-> Subacute poisoning characteristics of both acute and chronic poisoning.
-> It can show rapid onset of symptoms like acute poisoning but over a slightly longer duration or with a gradual worsening typical of chronic exposure.
-> Example: Regular exposure to carbon monoxide over a few weeks can lead to subacute poisoning, where symptoms might initially be mild and nonspecific but progressively worsen, blending acute and chronic poisoning features.
12. Define fulminant poisoning.
- Slow symptom development
- Fast symptom development
- Rapid death from massive dose
- Easily treatable mild poisoning
Answer and Explanation
Answer: (3) Rapid death from massive dose
Explanation:
-> Fulminant poisoning results in rapid death, often without prior symptoms, due to a large toxin dose.
-> Example: Ingesting a large amount of cyanide can cause fulminant poisoning, resulting in death within minutes leaving little to no time for symptoms to develop.
13. Given below are two statements:
Statement I: Toxinology focuses exclusively on the study of bacterial toxins and their effects on humans.
Statement II: Acute poisoning is distinguished by symptoms that develop rapidly after a single dose or multiple doses taken in a short timeframe.
In the light of the above statements, choose the correct answer from the options given below:
- Both Statement I and Statement II are true
- Both Statement I and Statement II are false
- Statement I is true but Statement II is false
- Statement I is false but Statement II is true
Answer and Explanation
Answer: (4) Statement I is false but Statement II is true
Explanation: Statement I is wrong because Toxinology is the science of the study of toxins produced by plants, animals, bacteria, and fungi that are harmful to human beings.
14. Which of the following correctly matches the type of poisoning with its description?
(a) Acute poisoning – Massive doses leading to rapid death
(b) Chronic poisoning – Excessive single dose causing immediate symptoms
(c) Subacute poisoning – Features of both acute and chronic poisoning
(d) Fulminant poisoning – Smaller doses over time resulting in gradual worsening
Choose the correct option from the list:
- (a) only
- (c) only
- (d) only
- (a) and (c)
Answer
Answer: (2) (c) only
15. Given below are two statements:
Statement I: Fulminant poisoning typically allows for a window of treatment due to its slow progression.
Statement II: Chronic poisoning occurs due to the accumulation of toxins over a prolonged period, often resulting in a gradual decline in health.
In the light of the above statements, choose the correct answer from the options given below:
- Both Statement I and Statement II are true
- Both Statement I and Statement II are false
- Statement I is true but Statement II is false
- Statement I is false but Statement II is true
Answer and Explanation
Answer: (4) Statement I is false but Statement II is true
Explanation: Statement I is wrong because Fulminant poisoning is marked by rapid, often fatal outcomes, sometimes without preceding symptoms, leaving little to no time for treatment.
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